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Dr. Wilma Barcellini


Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico
via Francesco Sforza, 35 20122 Milan • Italy
In the years 1997-2013 she worked at Hematologic Unit (inpatients, Day Hospital and outpatient ambulatory). She was involved into the diagnosis and research at the Laboratory for Diagnosis of Anemia, specifically focusing on the pathophysiology of anemia, haematological immune-mediated cytopenias, and autoimmune aspects in onco-hematology. With reference to these, the main fields of interest were: a) diagnosis and characterization of the pathophysiological mechanisms (biochemical, immunological and molecular) of congenital hemolytic anemia caused by red blood cell membrane and enzymes defects, and paroxysmal nocturnal emoglobimuria (Rare Diseases) b) identification of new genes in rare congenital hemolytic anemias (stomatocytosis,"unclassified" membrane defects, rare erythroenzymopathies) with validation of the diagnostic value of new mutations and genotype-phenotype correlation c) study of autoimmune phenomena and their role in the destruction of red blood cells in congenital hemolytic anemia caused by the red blood cell membrane defects d) development and validation of new diagnostic tools in difficult cases of DAT-negative autoimmune hemolytic anemia; study of the immunological basis and of cytochine regulation of anti-erythrocyte autoimmunity e) study of the effectiveness of new biologics drugs for autoimmune hemolytic anemias (rituximab, bortezomib) f) study of autoimmune phenomena in "early" myelodysplastic syndromes (refractory anemia and refractory anemia with ringed sideroblasts) and bone marrow aplasia/ paroxysmal nocturnal hemoglobinuria, with particular reference to autoimmunity directed against bone marrow precursors and apoptotic mechanisms involved g) role of anti-erythrocyte autoimmunity and immunoregolatory cytokines/ toll-like receptors in anemia associated with lymphoproliferative syndromes (chronic lymphocytic leukemia) and chronic myeloproliferative disorders (myelofibrosis) h) study of immune cytopenias ( immune-mediated thrombocytopenia and autoimmune / idiopathic neutropenia), with particular reference to a possible evolution in onco-hematological forms

Scientific publications

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Co-funded by the Health Programme of the European Union.