Gluthatione reductase deficiency

Gluthatione reductase (GR) activity is very sensible to the concentration of Vitamin B2 (Pyrophosphate of Tyamine) and measurement of its activity is useful for knowing vitamin B2 status. Only one case of congenital GR deficiency has been reported in a white woman with cataracts and acute haemolytic anaemia alter fava beans ingestion (favism). Clinical manifestations of GR deficiency are very similar to that of glucose -6 phosphate deshydrogenase (G6PD) deficiencies.