Congenital dyseryhtropoiesis anaemia type II

Clinical features and consequences of congenital dyserythropoietic anaemia type II are similar to CDA type I. It is transmitted by recessive inheritance. The diagnosis relies on morphologic examination of bone marrow and a positive acid serum lysis test with about 60% of normal sera or evidence of the membrane defect by special tests. Splenectomy can improve the anaemia in more severe cases. Iron overload may necessitate treatment by iron depletion.

Synonym:  Hereditary multinuclearity with positive acidified serum test (HEMPAS)