Aldolase is an enzyme of the anaerobic glycolytic pathway involved in cleaving fructose 1.6 diphosphate into triose phosphates.

Distribution

Aldolase A is predominant in muscle and red blood cells.

Laboratory and Clinical Picture

A deficiency of Aldolase A can lead to muscular disorders (myopathies) with exercise intolerance or breakdown of muscle fibres (rhabdomyolysis) associated with haemolytic anaemia.

Transmission Mode

The condition is transmitted as an autosomal recessive trait.